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Inhibition of JAK-STAT signaling by TG101348: a novel mechanism for inhibition of KITD816V-dependent growth in mast cell leukemia cells
ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2
CCO/N=C(/C1N=C(NP(O)(O)=O)SN=1)\C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3C=C[N+](C)=CC=3)=C(C(O)=O)N2C1=O
Chemical Name: (Z)-4-(4-((5-(4
21(22):7107-17
VLX1570 - CAS# 1431280-51-1 288 Inhibition of JAK-STAT signaling byVLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly
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