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Cenerimod Catalog No.:M13534-2 MALT1-MI-2 (MI-2) was intraperitoneally (IP)

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Description

MALT1-MI-2 (MI-2) was intraperitoneally (IP) dosed to mice at 25 mg/kg once per day for 14 days in TMD8 and HBL-1 ABC-DLBCL xenografts

2ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3

(2016) Nat Commun

play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth

Scott Busby

Cenerimod Catalog No.:M13534-2 MALT1-MI-2 (MI-2) was intraperitoneally (IP)Cenerimod (ACT 334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous. Product information CAS Number: 1262414 04 9 Molecular Weight: 453. 53

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