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Review Article - (2019) Volume 13, Issue 4 Jun Lei 1# , Lichun Sun 1,2,3#* , Ping Li 2 , Chenhong Zhu 2 , Zhen Lin 4 , Vienna Mackey 3 , David H Coy 3 and Quanyong He 1* 1 The Third Xiangya HospitaI of Central South University, Changsha, China 2 Sino-US Innovative Bio-Medical Center and Hunan Beautide Pharmaceuticals, Xiangtan, Hunan, China 3 Department of Medicine, School of Medicine, Tulane University Health Sciences Center, USA 4 Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, LA70112, USA # These authors contributed equally Received date: 02 July 2019 Accepted date: 15 July 2019 Published date: 22 July 2019 Citation: Lei J, Sun L, Li P, Zhu C, Lin Z, et al