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Formula: C18H20ClFN2O2
MHC-I–restricted antigens in vitro and in vivo with minimal cross-reactivity for the constitutive proteasome
induces cell cycle arrest and apoptosis and depletes client proteins in human cancer cells (80 nM)
WDR5-C47 was suggested to be used at 10 µM final concentration in vitro and in cellular assays
inducing epigenetic changes in leukemia cells and the expression of promoter methylated genes
FPS-ZM1 - CAS# 945714-67-0 0078 Formula: C18H20ClFN2O2FPS ZM1, CAS No. 945714 67 0, is a high affinity RAGE specific blocker that inhibits amyloid binding to RAGE, neurological damage and inflammation in the APP(sw 0) transgenic mouse model of AD. FPS ZM1 is not toxic to mice and can easily cross the blood brain barrier. AGEs administration induced an regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are