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Homo-PROTAC cereblon degrader 1
Gniadecki R
InChi: InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8
CAS Number: 1427782-89-5
InChi: InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7
Amrubicin - CAS# 110267-81-7 MG 837 Calcium hydrate Homo-PROTAC cereblon degrader 1Amrubicin, also known as SM 5887, is an anthracycline used in the treatment of lung cancer. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. This agent has demonstrated a higher level of anti tumor activity than conventional anthracycline drugs without exhibiting any indication of the cumulative
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