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These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML
InChiKey: RZEKVGVHFLEQIL-UHFFFAOYSA-N
KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion
Smiles: COC1=CC2=C(NC3=CC(Br)=C(O)C=C3)N=CN=C2C=C1OC
Epub 2013 Jan 8
WHI-P154 - CAS# 211555-04-3 Catalog No.:M6563-2 These data suggest that directWHI P154, CAS No. 211555 04 3, is a JAK3 inhibitor with IC50 = 1. 8 microM. WHI P154 displays no activity at JAK1 or JAK2. WHI P154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro . Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3 K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 microM). Product information CAS Number: 211555 04 3 Molecular
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