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The ability of LY-303511 to increase gap junctional intercellular communication (GJIC) does not occur concomitant with inhibition of phosphorylation of AKT as measured by immunoblotting
LGK974 potently inhibits Wnt signaling in vitro and in vivo
is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40
It dose-dependently reduces IRE1α kinase autophosphorylation in vitro with IC50 ~0
Front Physiol
BPTES - CAS# 314045-39-1 size:10mg solid The ability of LY-303511 toBPTES, CAS No. 314045 39 1, is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. BPTES has a K(i) of approx. 3 microM. BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex. Product information CAS Number: 314045 39 1 Molecular Weight: 524. 68 Formula:
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