BMH-21 - CAS# 896705-16-1 Catalog No.:M7093-2 CC1(N)CCN(CC1)C1=CN=C(C2=CC=CC(Cl)=C2Cl)C(N)=N1

CC1(N)CCN(CC1)C1=CN=C(C2=CC=CC(Cl)=C2Cl)C(N)=N1

is a toxic alkaloid found in various Amaryllidaceae species

RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells

PubMed Central PMCID: PMC3632326

Chemical Name: (2E)-1-(6

BMH-21 - CAS# 896705-16-1 Catalog No.:M7093-2 CC1(N)CCN(CC1)C1=CN=C(C2=CC=CC(Cl)=C2Cl)C(N)=N1BMH 21, CAS No. 896705 16 1, is a potent small molecule DNA intercalator. BMH 21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH 21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH 21 effects on the nucleolar stress response were independent of major DNA damage associated PI3 kinase pathways, ATM, ATR and DNA PKcs. BMH 21 is a chemically unique DNA intercalator that has high