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16(11):1069-79
InChiKey: GEPYBHCJBORHCE-SFHVURJKSA-N
Compound 401 is a potent inhibitor of DNA-PK (IC50=0
and in vivo in monkeys and humans
2009 Aug 20
FLI-06 - Notch Pathway Modulator. CAS# 313967-18-9 Catalog No.:M60149-10S 16(11):1069-79FLI 06, CAS No. 313967 18 9, is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2. 3 M), identified by using automated microscopy to monitor the trafficking and processing of a ligand independent Notch GFP fusion reporter. FLI 06 can induce accumulation of the reporter at the plasma membrane by interfering with transport in the secretory pathway. It can also disrupt the Golgi apparatus in