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InChiKey: YPWHZCPMOQGCDQ-HMGRVEAOSA-N
4-triol is an endogenous metabolite
and V-type ATPases are genetically and functionally related to F-ATPases but function only in ATP breakdown
Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCOCCN(CCOCCOCCOCCN)CCOCCOCCOCCOCCC(=O)OC(C)(C)C
HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2
JNJ28871063 hydrochloride - CAS# 944342-90-9 Size:Contact [email protected] for quotation InChiKey: YPWHZCPMOQGCDQ-HMGRVEAOSA-NJNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan ErbB kinase inhibitor with IC50 values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR
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