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11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17
Molecular Weight: 537
2-3H3/t24-
CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer
InChi: InChI=1S/C30H46O5/c1-25(2)13-14-30(24(34)35)19(15-25)18-7-8-21-26(3)11-10-22(32)27(4
(R)-CR8 trihydrochloride Size:10mg solid 11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17(R) CR8 (CR8) trihydrochloride, a second generation analog of Roscovitine, is a potent CDK1 2 5 7 9 inhibitor. (R) CR8 trihydrochloride inhibits CDK1 cyclin B (IC50=0. 09 M), CDK2 cyclin A (0. 072 M), CDK2 cyclin E (0. 041 M), CDK5 p25 (0. 11 M), CDK7 cyclin H (1. 1 M), CDK9 cyclin T (0. 18 M) and CK1 (0. 4 M). (R) CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R) CR8 trihydrochloride acts as a molecular glue degrader that