N-(Boc-PEG4)-NH-PEG4-NH-Boc 17943 CP-533536 demonstrates excellent in vitro

CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets

C2H4O2/c1-18-101(10)162(200(328)240-123(54-60-159(292)293)185(313)245-130(75-110-81-220-114-41-26-25-40-112(110)114)190(318)242-125(70-97(2)3)187(315)232-116(43-28-30-63-212)180(308)246-131(77-149(278)255-203-166(230-107(16)273)168(297)171(146(94-269)337-203)339-207-170(299)169(298)167(296)147(338-207)95-336-210(208(334)335)80-143(275)165(229-106(15)272)145(340-210)79-142(274)144(276)93-268)176(304)223-83-150(279)221-87-154(283)259-65-32-45-138(259)197(325)252-136(91-266)196(324)250-134(89-264)177(305)225-84-151(280)227-103(12)204(331)261-67-34-47-140(261)206(333)262-68-35-48-141(262)205(332)260-66-33-46-139(260)198(326)249-133(88-263)172(215)300)257-192(320)128(73-108-36-21-19-22-37-108)244-188(316)126(71-98(4)5)241-181(309)117(44-31-64-219-209(216)217)239-199(327)161(100(8)9)256-173(301)102(11)228-178(306)120(51-57-156(286)287)235-183(311)121(52-58-157(288)289)236-184(312)122(53-59-158(290)291)237-186(314)124(61-69-341-17)238-182(310)119(49-55-148(214)277)234-179(307)115(42-27-29-62-211)233-194(322)135(90-265)251-189(317)127(72-99(6)7)243-191(319)132(78-160(294)295)247-195(323)137(92-267)253-202(330)164(105(14)271)258-193(321)129(74-109-38-23-20-24-39-109)248-201(329)163(104(13)270)254-153(282)86-224-175(303)118(50-56-155(284)285)231-152(281)85-222-174(302)113(213)76-111-82-218-96-226-111

InChiKey: VRVJKILQRBSEAG-LFPIHBKWSA-N

CAS Number: 153653-30-6

CF53 (Compound 28) binds to both the BD1 and BD2 domains of BRD2

N-(Boc-PEG4)-NH-PEG4-NH-Boc 17943 CP-533536 demonstrates excellent in vitroN (Boc PEG4) NH PEG4 NH Boc is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 2112737 17 2 Molecular Weight: 640. 80 Formula: C30H60N2O12 Chemical Name: tert butyl 1 {[(tert butoxy)carbonyl]amino} 3,6,9,12,18,21,24,27 octaoxa 15 azatriacontan 30 oate Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCOCCNCCOCCOCCOCCOCCNC(=O)OC(C)(C)C InChiKey: AFDJSRZVXYKUQT UHFFFAOYSA N InChi: InChI=1S C30H60N2O12 c1 29(2,3)43