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N-[4-[2-methoxyethyl(methyl)amino]phenyl]-2-phenyl-5-(trifluoromethyl)-1
24 hours) treatment of human SCC cells induces cell differentiation
I 893 dihydrochloride
Gabaldón C
InChi: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4
BI-D1870 - CAS# 501437-28-1 Catalog No.:M11147-2 N-[4-[2-methoxyethyl(methyl)amino]phenyl]-2-phenyl-5-(trifluoromethyl)-1BI D1870 is a potent and specific RSK inhibitor (the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 1030 nM. BI D1870 exhibited a dose responsive antiproliferative effect on OSCC cells with relative sparing of normal human oral keratinocytes. The compound inhibited the downstream RSK target YB 1 and caused apoptosis. In addition, BI D1870 also induced G2 M arrest by modulating the expression of p21 and