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Formula: C18H18Cl2N4O
It also inhibits the proliferation of U87MG
(2015) PCT WO 2015018060
2095432-58-7 (SAG HCl)
It induced a 50% loss of H3K27me3 in both EZH2 wild-type and mutant DLBCL cell lines at nM concentrations independent of EZH2 mutation status
PR-619 - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 2645-32-1 268 Formula: C18H18Cl2N4OPR 619, CAS No. 2645 32 1, is a cell permeable, non selective, reversible broad range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1 20 M. PR 619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose and time dependent manner (20 to 150 M, 0. 5 to 20 h) without direct impairment of proteasomal proteolysis. PR 619 treatment results in upregulation of both K48 and K63 linked polyUb chains. It induces
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