(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide

5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide

3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

TUNEL assay and the analysis of Caspase 3/7 and PARP indicated that BGT226 induced cancer cell death through an apoptosis independent pathway

JK184 was suggested to use at 1-5 µM concentration in vitro and in the cellular assays

Biochem Biophys Res Commun

(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamideMutations, CAS No. 103404 90 6, in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, such as leukemia and glioma, and result in overproduction of the (R) enantiomer of 2 hydroxyglutarate [(R) 2 HG]. Elucidation of the role of IDH mutations and (R) 2 HG in leukemogenesis has been hampered by a lack of appropriate cell based models. It has been recently reported that a canonical IDH1 mutant, IDH1