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Formula: C12H14N2O2
Chemical Name: N-(6-((2S
Smiles: CC1C=CC(=CC=1)S(=O)(=O)C1=CC=C(O1)[N+]([O-])=O
2/6/24 hours) dramatically decreases the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC
Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains
BAY-2416964 - CAS# 2242464-44-2 Catalog No.:M7082-2 Formula: C12H14N2O2BAY 2416964, CAS No. 2242464 44 2, is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY2416964 specifically binds to AhR, inhibits AhR activation, and prevents AhR mediated signaling. Abrogation of AhR activation prevents the activation of immune tolerant dendritic cells (DCs) and regulatory T cells (Tregs) in the tumor microenvironment (TME). This may
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