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exhibits a submicromolar IC50 in 10 of 10 multiple myeloma cell lines (MM1
CAS Number: 883065-90-5
including colorectal (HCT-116)
PF-06447475
and the Bax/Bcl-2 ratio
BRD PHOTAC-I-3 Catalog No.:M7566-10 exhibits a submicromolar IC50 inBRD PHOTAC I 3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC I 3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+) JQ1 (Cat. No. 4499). Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark. Product information CAS Number: 2370997 94 5 Molecular Weight:
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