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48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12
and HL60 (myeloid)
APX-115 free base
Compound 34 induced a dose-dependent reduction in tumor volume and up to 68% tumor growth inhibition at the highest dose of 10 mg/kg b
suggesting that Müller survival pathways might underlie the neuroprotective response
MS432 Catalog No.:M17528-C 48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12MS432 is a first in class and highly selective PD0325901 based VHL recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively. Product information Molecular Weight: 1076. 06 Formula: C50H65F3IN7O6S Chemical Name: (2S, 4R) 1 [(2S) 2 [11 [3 [[3, 4 difluoro 2 (2 fluoro 4 iodoanilino)benzoyl]amino]oxypropylamino]undecanoylamino] 3, 3