PFI-1 - BET Inhibitor. CAS# 1403764-72-6 size:2 mg solid 9 nM and 1

9 nM and 1

and serves as a basis for new selective inhibitors of other HDAC isoforms

and CDK1 with IC50 of 35 nM

3(11):1427-38

Chemical Name: 7-(3

PFI-1 - BET Inhibitor. CAS# 1403764-72-6 size:2 mg solid 9 nM and 1PFI 1, CAS No. 1403764 72 6, is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4 with IC50 of ~98 nM and 220 nM respectively. Co crystal structures showed that PFI 1 acts as an acetyl lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD2 and BRD4. It has an EC50 of 1. 89 M for the inhibition of IL6 production from human blood mononuclear cells