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CAS Number: 158876-82-5
InChiKey: ISCHOARKJADAKJ-UHFFFAOYSA-N
Polo-like kinases inhibited by wortmannin
29(3):397-402
17)18)10-5-12(19-2)7-13(6-10)20-3
Bay 60-7550 - CAS# 439083-90-6 Size:Solid 10 mg CAS Number: 158876-82-5BAY 60 7550 is a potent PDE2 inhibitor with IC50 values of 2. 0 nM (bovine) and 4. 7 nM (human). BAY 60 7550 antagonizes oxidative stress induced anxiety like behavioral effects in mice by increasing cGMP signaling. Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP cGMP levels. These second messengers play important regulatory roles in controlling steroidogenesis in the adrenal. Disruption of PDEs has been associated with a
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