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It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM
Semisynthetic routes to PF1022H--A precursor for new derivatives of the anthelmintic cyclooctadepsipeptide PF1022A
2013 Apr 11
24-diazanidahexacyclo[18
1021/ml900025z
SB-218078 - CAS# 135897-06-2 60329 It binds to the enzymeSB 218078, CAS No. 135897 06 2, is a potent and selective indolocarbazole chk1 inhibitor. Product information CAS Number: 135897 06 2 Molecular Weight: 393. 39 Formula: C24H15N3O3 Chemical Name: (5R,8S) 7,8 dihydro 5H 16 oxa 4b,8a,14 triaza 5,8 methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e] as indacene 13,15(6H,14H) dione Smiles: O=C1NC(=O)C2=C1C1=C3C4=C2C2=CC=CC=C2N4C2CCC(O2)N3C2=CC=CC=C21 InChiKey: OTPNDVKVEAIXTI UHFFFAOYSA N InChi: InChI=1S
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