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((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3
Domchek SM
19)20)22-23(14)12-5-7-13(8-6-12)26(21
Degraders of wee1 kinase
Chemical Name: 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}-1
NV-5138 C AR Degrader-4 TFA ((4-((4-hydroxy-3-(1-methylethyl)phenyl)methyl)-3NV 5138 is an orally and centrally active small molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal