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inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM
Hussaini I
InChiKey: JYGXADMDTFJGBT-VWUMJDOOSA-N
Molecular Weight: 385
Smiles: C[C@H](NC(=O)/C(=C/C1=CC=CC(Br)=N1)/C#N)C1C=CC=CC=1
Ruxolitinib sulfate - CAS# 1092939-16-6 alog 2 inhibiting Cdc28p and Pho85p (IC50sRuxolitinib sulfate is the first potent, selective JAK1 2 inhibitor to enter the clinic with IC50s of 3. 3 nM 2. 8 nM, and has > 130 fold selectivity for JAK1 2 versus JAK3. Ruxolitinib potently and selectively inhibits JAK2V617F mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nM results in a doubling of cells with depolarized mitochondria in Ba F3 cells. Ruxolitinib demonstrates remarkable