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1-10 mg/kg once or twice per day to achieve good efficacy in xenograft models
Smiles: O=C(NC1=CC=CN=N1)N1CCC(CC1)=CC1=CC(=CC=C1)OC1=CC=C(C=N1)C(F)(F)F
I-BET151 is also an ApoA1 upregulator that was also found to mediate potent anti-inflammatory effects
InChi: InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12
(-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ
Mal-PEG12-acid 0843 1-10 mg/kg once or twiceMal PEG12 acid is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 2445165 75 1 Molecular Weight: 697. 77 Formula: C31H55NO16 Chemical Name: 1 (2,5 dioxo 2,5 dihydro 1H pyrrol 1 yl) 3,6,9,12,15,18,21,24,27,30,33,36 dodecaoxanonatriacontan 39 oic acid Smiles: OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O InChiKey: FRRHLQYEWMQTLF UHFFFAOYSA N InChi: InChI=1S C31H55NO16 c33 29 1 2
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