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2008 Nov 1
Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death
including G protein-dependent activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and recruitment of β-arrestin
is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC)
CFI-402257
TAS-116 - CAS# 1260533-36-5 Catalog No.:M6713-10 2008 Nov 1TAS 116, CAS No. 1260533 36 5, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo radiosensitizing activities. TAS 116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent signaling, induces apoptosis, and