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regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53
it markedly augments the capacity of HGF at 1
(2011) Proc Natl Acad Sci USA
It was shown to reduce S-phase cells and induce G1-phase cells in A2780 cells
Grobelny D
YM-155 - a survivin inhibitor. CAS# 781661-94-7 0263 regulating deubiquitination activity of USP10YM 155, CAS No. 781661 94 7, is a novel survivin suppressant with an IC50 of 0. 54 nM for the inhibition of survivin promoter activity. Sepantronium bromide, also known as YM 155, is a small molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and