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125 μg/mL to 4 μg/mL
No next-day hangover effects were observed
in liver microsomes of rats
InChi: InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H
RG3039 (PF-06687859
CI-1040 (PD184352) Size:10mg solid 125 μg/mL to 4 μg/mLCI 1040, also known as PD184352, is a MEK inhibitor, which demonstrated in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI 1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated. Product information CAS Number: 212631 79 3 Molecular Weight: 478. 66 Formula: C17H14ClF2IN2O2 Synonym: CI1040