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5-trihydroxyoxan-2-yl]oxy}-3
InChi: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12
18)/t12-/m1/s1
and largely abolishs MCF7 tumor growth in implanted athymic mice
CAS Number: 950912-80-8
Corynoxine B spinesib (SB-715992) 5-trihydroxyoxan-2-yl]oxy}-3Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin 1 dependent autophagy inducer. IC50 value: Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA HMGB1 interaction . in vivo: Corynoxine B exhibited prolongation
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