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GV196771 is a potent antagonist of the modulatory glycine site of the NMDA receptor developed for treatment of neuropathic pain
and incidence of relapses
NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1
L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA
pp 850–855
Apremilast D5 18274 GV196771 is a potent antagonistApremilast D5 (CC 10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type 4 cyclic nucleotide phosphodiesterase (PDE 4) with an IC50 of 74 nM. Apremilast inhibits TNF release by lipopolysaccharide (LPS) with an IC50 of 104 nM. Product information CAS Number: 1258597 47 5 Molecular Weight: 465. 53 Formula: C22H24N2O7S Chemical Name: N {2 [(1S) 1 {3 [(1,1,2,2,2 H)ethoxy] 4 methoxyphenyl} 2 methanesulfonylethyl]
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