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Smiles: CNC(=O)C1=CC(=CC=N1)OC1=CC(F)=C(C=C1)NC(=O)NC1=CC(=NN1C1=CC2=CC=CN=C2C=C1)C(C)(C)C
2 µM to completely block Wnt protein secretion
20-heptaoxadocosan-22-yloxy)-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9
Formula: C40H38ClNO5
It demonstrates that high selectivity and potent inhibition of HDAC6 can be achieved through careful choice of linker element only
Vandetanib - CAS# 443913-73-3 CRABP-II Degrader-1 Smiles: CNC(=O)C1=CC(=CC=N1)OC1=CC(F)=C(C=C1)NC(=O)NC1=CC(=NN1C1=CC2=CC=CN=C2C=C1)C(C)(C)CVandetanib is an orally bioavailable 4 anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell
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