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the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding
The metabolites are excreted in the urine and feces
33 mg/mL (105
35(9):1035-42
11μM to 0
GS-626510 Compound Library the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitutionGS 626510 is a potent, and orally active BET family bromodomains inhibitor, with Kd values of 0. 59 3. 2 nM for BRD2 3 4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively. Product information CAS Number: 1637770 13 8 Molecular Weight: 394. 47 Formula: C25H22N4O Chemical Name: 5 [2 cyclopropyl 5 (3,5 dimethyl 1,2 oxazol 4 yl) 1H 1,3 benzodiazol 7 yl] 6 methylquinoline Smiles: CC1=CC=C2N=CC=CC2=C1C1C=C(C=C2N=C(NC=12)C1CC1)C1C(C)=NOC=1C
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