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CAS Number: 938440-64-3
The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells
CAS Number: 23279-22-3
IV pharmacokinetics are characterized by moderate clearance in rat and low clearance in dog
InChiKey: IWBOPFCKHIJFMS-UHFFFAOYSA-N
TD52 - CAS# 1798328-24-1 4363 CAS Number: 938440-64-3TD52, an Erlotinib (HY 50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple negative breast cancer (TNBC) cells via regulating the CIP2A PP2A p Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p EGFR inhibition and has potent anti cancer activity. Product information CAS Number: