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but only activatedRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested
InChi: InChI=1S/C27H26F3NO3/c1-18-20(9-6-10-23(18)21-7-4-3-5-8-21)12-13-22-15-19(11-14-24(22)27(28
InChi: InChI=1S/C15H14ClNO3
SJG-136 shows more potent antitumor effect against CMeC-1 tumour at 0
Oral administration of SAR-260301 reveals sustained target inhibition (≥50%) of pAkt-S473 for at least 7 h
Polygalacic acid 7781 but only activatedRARβ and RARγPolygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and
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