TAS-102 - CAS# 733030-01-8 Catalog No.:M6637-10S Smiles: CC(C)C1=CC(=NNC1=O)OC1C(Cl)=CC(=CC=1Cl)N1N=C(C#N)C(=O)NC1=O

Smiles: CC(C)C1=CC(=NNC1=O)OC1C(Cl)=CC(=CC=1Cl)N1N=C(C#N)C(=O)NC1=O

1038/s41598-017-00212-w

14(15):1837-51

Rational combinations of enzastaurin with novel targeted agents for patients with B-cell non-Hodgkin's lymphoma

Meininger G

TAS-102 - CAS# 733030-01-8 Catalog No.:M6637-10S Smiles: CC(C)C1=CC(=NNC1=O)OC1C(Cl)=CC(=CC=1Cl)N1N=C(C#N)C(=O)NC1=OTAS 102, CAS No. 733030 01 8, is an investigational drug candidate for metastatic colorectal cancer. It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 1; 0. 5. Trifluridine is a nucleoside analog, and tipiracil hydrochloride is a thymidine phosphorylase inhibitor, which prevents rapid metabolism of trifluiridine, increasing the bioavailability of trifluiridine. After oral administration of TAS 102, TFT is