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stimulates periosteal bone formation in monkeys
and MDA-MB436 ER negative breast cancer cells
and has slight activity against HDAC8 (IC50 ~0
6-dihydro-4H-pyrrolo[1
10 mM SB431542
Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid stimulates periosteal bone formation inRapamycin, CAS No. 53123 88 9, is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism
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