LY-411575 (isomer 3) nserin InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9

InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9

By the oral route

Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds

Smiles: COC1C=C(NC2=NC3=CC=CC=C3N=C2NS(=O)(=O)C2C=C(C=CC=2)NC(=O)C(C)(C)N)C(Cl)=CC=1

27(31)34)15-25(32)33/h6-13

LY-411575 (isomer 3) nserin InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9LY 411575 isomer 3, is an isomer of LY411575, which is a potent, cell permeable secretase inhibitor (IC50= 0. 078 nM 0. 082 nM (in membrane assay in cell based secretase assays)) and also inhibits Notch clevage (IC50= 0. 41 nM). Product information CAS Number: 2070009 28 6 Molecular Weight: 479. 48 Formula: C26H23F2N3O4 Synonym: LY411575 isomer 3 LY 411575 isomer 3 Chemical Name: (2R) 2 [(2R) 2 (3, 5 difluorophenyl) 2 hydroxyacetamido] N [(10S) 8