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PPQ-102 is a potent and voltage-independent CFTR inhibitor which completely inhibit CFTR chloride current with IC50 approximately 90 nM
Molecular Weight: 360
Smiles: C[C@H]1C=CC=CCCC=CC=CC=CC=CC(CC2O[C@](O)(CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@@H]1O)CC(O)C2C(O)=O)O[C@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O |t:2
including T315I
Nifuratel is a local antiprotozoal and antifungal agent that may also be given orally
Torcetrapib 02895 Hydrochloride PPQ-102 is a potent andTorcetrapib, also known as CP 529,414 was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease. Its development was halted in 2006 when phase III studies showed excessive all cause mortality in the treatment group receiving a combination of atorvastatin (Lipitor) and torcetrapib. Torcetrapib acts (as a CETP inhibitor) by inhibiting cholesterylester transfer protein (CETP), which normally
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