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it is selectively and irreversibly converted to its active phosphoramidate-based
InChiKey: FAZZYPIBZBGQSH-UHFFFAOYSA-N
InChi: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10
It inhibits the conjugation of Ub to a range of E2 enzymes and inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity
Lariviere WR
SU-5402 - FGFR inhibitor. CAS# 215543-92-3 size:2mg solid it is selectively and irreversiblySU 5402, CAS No. 215543 92 3, is a potent inhibitor of FGFR, VEGFR, and PDGFR. SU 5402 has been used in many studies to inhibit cancer cell growth, or modulate stem cell phenotypes, including maintenance of mouse ESCs, or inducing generation of functional human nociceptors from human ESCs iPSCs when combined with LDN193189 BMP inhibitor, SB431542 TGF inhibitor, CHIR99021 GSK3 inhibitor, and DAPT Notch inhibitor. Product information CAS Number: 215543
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