GBR 12935 Catalog No.:M8659-2 JCI Insight

JCI Insight

ML-180 is inactive for steroidogenic factor-1 (SF-1

It binds at the ATP-binding cleft of the enzyme

6-dichlorophenyl)-1H-imidazol-2-amine

nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

GBR 12935 Catalog No.:M8659-2 JCI InsightGBR 12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (I) are now available for this