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ACAT-IN-7 inhibits NF-κB mediated transcription
InChi: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11
29)/b13-6+
115(11):2251-9
Chemical Name: (2S)-N
CDK12-IN-4 bic acid 2-phosphate ACAT-IN-7 inhibits NF-κB mediated transcriptionCDK12 IN 4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0. 641 M at high ATP (2 mM). CDK12 IN 4 has no effect on CDK2 Cyclin E (IC50>20 M) and CDK9 Cyclin T1 (IC50>20 M) at high ATP (2 mM) (WO2021116178A1). Product information CAS Number: 2651196 69 7 Molecular Weight: 426. 42 Formula: C20H20F2N8O Chemical Name: 8 cyclopropyl N ((6, 7 difluoro 1H benzo[d]imidazol 2 yl)methyl) 2 morpholinopyrazolo[1, 5 a][1, 3, 5]triazin 4 amine
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