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ClH/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19
resulting in the inhibition of mitosis
Thalidomide-O-C11-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology
in the absence or presence of the unlabelled p53 consensus oligonucleotide) restores p53-specific DNA binding activity to p53R273H (a DNA contact mutant) and p53R175H (a structural mutant) in WiDr colon tumour cells harbouring p53R273H and KLE cells with p53R175H
InChi: InChI=1S/C141H222N43O39PS3
AZD-8835 stin-LR ClH/c22-12-3-4-14-26(15-20-24-17-9-1-2-10-18(17)25-20)19-11-5-7-16-8-6-13-23-21(16)19AZD8835 is a potent and selective inhibitor of PI3K and PI3K with IC50s of 6. 2 and 5. 7 nM, respectively. Product information CAS Number: 1620576 64 8 Molecular Weight: 469. 54 Formula: C22H31N9O3 Chemical Name: 1 (4 {5 [5 amino 6 (5 tert butyl 1,3,4 oxadiazol 2 yl)pyrazin 2 yl] 1 ethyl 1H 1,2,4 triazol 3 yl}piperidin 1 yl) 3 hydroxypropan 1 one Smiles: CCN1N=C(N=C1C1C=NC(N)=C(N=1)C1=NN=C(O1)C(C)(C)C)C1CCN(CC1)C(=O)CCO InChiKey: ZGRDYKFVDCFJCZ
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