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monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity
39(1):6-13
50)36-18-15-32-21-35(51-6)17-14-33(32)22-36
'rescuing' the patient while permitting the antitumor activity of the folate antagonist
Formula: C30H44N2O14
AG-370 Catalog No.:M22560-C monovalent mimetic of second mitochondrial-derivedIC50: 20 M for PDGF receptor kinase in human bone marrow fibroblasts AG 370 is a tyrphostin PDGFR inhibitor. Protein tyrosine kinase inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of protein tyrosine kinases. Tyrphostins are a class of antiproliferative agents selectively inhibiting protein tyrosine kinases of key growth factors including epidermal growth factor or platelet derived growth factor (PDGF) via