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It shows modest general cytotoxicity
a potent and selective Mps1/TTK kinase inhibitor
Crenolanib (10 mg/kg and 20 mg/kg) suppresses non-small-cell lung cancer tumor growth in vivo and induces tumor cell apoptosis
Smiles: O=C1NC(=O)C(=C1C1=CN=C2C=CC=CN21)C1C=CC2CNC(CN3C(F)=CC=1C3=2)C(=O)N1CCCCC1
synthesis thereof and intermediates thereto
Y-27632 - Rock Inhibitor. CAS# 146986-50-7 60268 It shows modest general cytotoxicityY 27632, CAS No. 146986 50 7, is a widely used, selective inhibitor of the Rho associated protein kinase p160ROCK with a Ki value at ~ 0. 14 M. In many studies, it was shown and used to enhance the survival and cloning efficiency of many primary cell types after single cell dissociation without affecting their self renewal properties, including hESC iPSCs, neural stem cells, intestinal stem cells, and mammary epithelial cells. Product information CAS