PF-06372865 Catalog No.:M14974-2 Smiles: COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1

Smiles: COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1

induces the apoptotic cell death of MCF-7 cells by increasing Bax expression level

InChiKey: OINVVPOIGFSNHM-VLIAUNLRSA-N

InChi: InChI=1S/C22H44O7S/c23-22(24)10-12-26-14-16-28-18-20-29-19-17-27-15-13-25-11-8-6-4-2-1-3-5-7-9-21-30/h30H

subcutaneous injection) to mice bearing GM-CSF-secreting B16 tumors

PF-06372865 Catalog No.:M14974-2 Smiles: COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1PF 06372865 is an orally active, 2 3 5 subtype selective GABAA positive allosteric modulator (PAM). PF 06372865 is a high affinity ligand at GABAA receptors containing 1 2 3 5 subunits (Kis of 2. 9 nM, 21 nM, 134 nM for 2, 1 PAM, 2 PAM, respectively), with low affinity for 4 6 subunits. PF 06372865 can across the blood brain barrier (BBB). PF 06372865 has anxiolytic activity and has the potential for epilepsy. Product information CAS Number: 1614245