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Ocular hypotensive efficacy
Smiles: CC[C@]1(O)C2C=C3C4=NC5=CC=CC=C5C=C4CN3C(=O)C=2COC1=O
Pelitinib at 75-500 nM also specifically inhibits the activation of AKT and ERK1/2
InChi: InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6
C#CCCC([O-])=O
Sobetirome - CAS# 211110-63-3 inib (S) Ocular hypotensive efficacySobetirome, also known as GC 1 and QRX 431, is a hyroid hormone beta receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through