GZD824 - CAS# 1257628-77-5 ne Protease inhibitor Hydrochloride Apoptosis Activator 2 is a

Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively

2015 Nov 15

giving growth delays in A431 xenografts exceeding 50 days following oral administration

91 μM for UMSCC10b cells

Suppression of the clinical and cytokine response to endotoxin by RWJ-67657

GZD824 - CAS# 1257628-77-5 ne Protease inhibitor Hydrochloride Apoptosis Activator 2 is aOlverembatinib, also known as GZD824, is a novel orally bioavailable inhibitor against a broad spectrum of Bcr Abl mutants including T315I. GZD824 tightly bound to Bcr Abl(WT) and Bcr Abl(T315I) with K(d) values of 0. 32 and 0. 71 nM, respectively, and strongly inhibited the kinase functions with nanomolar IC(50) values. GZD824 potently suppressed proliferation of Bcr Abl positive K562 and Ku812 human CML cells with IC(50) values of 0. 2 and 0. 13 nM,