Rhynchophylline C3-piperazine-N-Boc 5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamido)ethyl)-3-(4-((2

5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamido)ethyl)-3-(4-((2

Smiles: CC1C=CC(=CC=1)C(=O)NC1SC(NC2C=CC=CC=2)=NC=1C(N)=O

InChiKey: OHEHXCOAADLDFL-JMTVWKGYSA-N

4-c]furan-1-yl)-2-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3

76(9):2710-9

Rhynchophylline C3-piperazine-N-Boc 5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamido)ethyl)-3-(4-((2Rhyncholphylline, an alkaloid isolated from Uncaria, shows potent inhibition of lipopolysaccharide (LPS) induced NO production in rat primary microglial cells. IC50 value: Target: In vitro: Rhyncholphylline effectively suppresses release of proinflammatory cytokines in LPS activated microglial cells and the underling molecular mechanism for the inhibition of microglial activation; Attenuated LPS induced production of proinflammatory cytokines such as