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12-dione hydrochloride
is a potent and selective histamine 1 (H1) antagonist
InChi: InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18
Ro 31-8220 directly suppresses voltage-dependent Na+ channels
17(4):641-51
Nilotinib (monohydrochloride monohydrate) - CAS# 923288-90-8 rasirox (Fe3+ chelate) 12-dione hydrochlorideNilotinib, also known as AMN107, is a small molecule tyrosine kinase inhibitor approved for the treatment of imatinib resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr Abl kinase inhibitor that is 10 30 fold more potent than imatinib in inhibiting Bcr Abl tyrosine kinase activity and
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