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3-oxazol-2-yl)(H)propanoic acid
InChi: InChI=1S/C16H22O3/c1-11-8-12(10-16(2
2012 Jun 14
2014 Jan 23
October 2015 Oct 25:259-260
NBD-556 tisone 3-oxazol-2-yl)(H)propanoic acidNBD 556 is a HIV 1 entry inhibitor. NBD 556 inhibited cellcell fusion between H9 HIV 1IIIB and MT 2 (IC50 ~3 M). NBD 556 prevent gp120 binding to CD4. The HIV 1 entry into host cells is a complex, multi factors involved, and multi step process. Especially, the attachment of HIV 1 envelope glycoprotein gp120 to the host cell receptor CD4 is the first key step during entry process, representing a promising antiviral therapeutic target. Product
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