Mutant IDH1-IN-4 terhydrate MI-2 was used at 10-25

MI-2 was used at 10-25 µM concentration in vitro and in the cellular assays

The P2Y2 receptor agonist Denufosol (INS37217) improves the rate of retinal reattachment in animal models of induced retinal detachment (RD)

All compounds tested inhibit H+ secretion in a concentration dependent manner with IC50 values of 8

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

38-log CFU reductions

Mutant IDH1-IN-4 terhydrate MI-2 was used at 10-25Mutant IDH1 IN 4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of 0. 5 M for mutant IDH1 in R132H, HT1080 and U87R132H cells. Product information CAS Number: 1416270 18 2 Molecular Weight: 438. 56 Formula: C25H34N4O3 Chemical Name: 8 cyclopropyl 6 [(3R) 3 cyclopropyl 4 (3 methoxypropanoyl)piperazin 1 yl] 3,3 dimethyl 1H,3H,4H pyrano[3,4 c]pyridine 5 carbonitrile Smiles: